![]() ![]() Recently, the intervention of dietary factors in CVD has attracted attention because it is often easily accepted ( 4). Due to the heavy social and family burden of CVD, early intervention and prevention strategies are particularly important ( 3). And it is expected to rise to 23.6 million by 2030 ( 2). Globally, CVD remains a rising global epidemic, with more than 17 million deaths due to CVD annually, according to world Health Organization estimates ( 1). Further large randomized controlled trials should be conducted to confirm the causal effect of tea consumption on cardiovascular disease risk.Ĭardiovascular disease (CVD) is the result of complications in the heart and blood vessels. Sensitivity analyses found little evidence of pleiotropy.Ĭonclusion: Our two-sample MR analysis provided genetic evidence that tea intake was significantly associated with a reduced risk of hypertension, heart failure, and ischemic stroke, and that hypertension may be a potential mediator. And the association between tea drinking and the risk of heart failure and ischemic stroke may be mediated by hypertension. Results: One standard deviation increase in tea intake was associated with a 25% (OR = 0.75, 95%CI = 0.61–0.91, p = 0.003) lower risk of hypertension, a 28% (OR = 0.72, 95%CI = 0.58–0.89, p = 0.002) lower risk of heart failure, and a 29% (OR = 0.71, 95%CI = 0.55–0.92, p = 0.008) lower risk of ischemic stroke, respectively. A further sensitivity analysis was performed to ensure robustness of the results. Inverse variance weighted MR analysis was used as the primary method for causal analysis. In the second step, we examined the association of hypertension with heart failure and ischemic stroke and estimated the mediating effect of hypertension. In the first step we explored the causal effect of tea intake and CVD. ![]() Summary data on cardio-vascular disease came from different GWAS meta-analysis studies. Methods: Genetic instruments for tea intake were identified from a genome-wide association studies (GWAS) involving 447,485 people. Furthermore the mediating effect of hypertension was also explored by a two-step MR. We used a two-sample Mendelian randomized (MR) analysis to systematically explore the causal relationship between tea intake and CVD subtypes for the first time. There is no unified conclusion about the potential relationship between tea drinking and CVD. Department of Cardiovascular Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Chinaīackground: Although studies suggest that tea consumption is associated with a reduced risk of cardiovascular disease (CVD).Ning Gao †, Ming Ni †, Jiangwei Song, Minjian Kong, Dongdong Wei and Aiqiang Dong * ![]()
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